Stable [64Cu]-labelled Phthalocyanine bioconjugates for development of potential PET probes. In vivo biodistribution imaging

Published in: J.Porphyrins Phthalocyanines 26 (2022) 376-283

Authors: Vanessa A. Tomé, Ângela C. B. Neves, Sara M. A. Pinto, Fábio M. S. Rodrigues, Mário J. F. Calvete, Vítor H. P. Alves, José Sereno, Antero J. Abrunhosa and Mariette M. Pereira

Abstract

The development of stable vectorized probes for application in medical imaging, particularly in PET, has been of great interest over the last few years. In this work, we report an efficient and straightforward (5 minute) radiolabeling methodology using [64Ni](p,n)[64Cu], produced in ICNAS medical cyclotron, using water as solvent.

The new [64Cu]-radiolabelled phthalocyanine complex, bearing choline moieties, a known key vector for breast cancer, was obtained with a RCC (radiochemical conversion) of 99%, presenting a high radiochemical stability.

In vivo PET imaging/biodistribution studies, performed in BALB/c mice showed that the main excretion pathway was via the hepatobiliary pathway.

Read more in: https://doi.org/10.1142/S1088424622500298